Frailty Related to Anesthesia guided by the Index "bispectraL" (FRAIL) study: study protocol for a randomized controlled trial.
Identifieur interne : 000C25 ( Main/Exploration ); précédent : 000C24; suivant : 000C26Frailty Related to Anesthesia guided by the Index "bispectraL" (FRAIL) study: study protocol for a randomized controlled trial.
Auteurs : Morgan Le Guen [France] ; Marie Herr [France] ; Antoine Bizard [France] ; Caroline Bichon [France] ; Nathalie Boichut [France] ; Thierry Chazot [France] ; Ngai Liu [France] ; Joel Ankri [France] ; Marc Fischler [France]Source :
- Trials [ 1745-6215 ] ; 2017.
Descripteurs français
- KwdFr :
- Anesthésie générale (effets indésirables), Anesthésie générale (mortalité), Cognition (MeSH), Exercice physique (MeSH), Facteurs de risque (MeSH), Facteurs temps (MeSH), Facteurs âges (MeSH), Femelle (MeSH), Force musculaire (MeSH), Fragilité (diagnostic), Fragilité (mortalité), Fragilité (physiopathologie), Fragilité (psychologie), France (MeSH), Humains (MeSH), Moniteurs d'évaluation de la conscience (MeSH), Monitorage neurophysiologique peropératoire (effets indésirables), Monitorage neurophysiologique peropératoire (instrumentation), Monitorage neurophysiologique peropératoire (méthodes), Mâle (MeSH), Méthode en simple aveugle (MeSH), Personne âgée fragile (MeSH), Plan de recherche (MeSH), Protocoles cliniques (MeSH), Résultat thérapeutique (MeSH), Sujet âgé (MeSH), Valeur prédictive des tests (MeSH), État nutritionnel (MeSH), Évaluation gériatrique (MeSH).
- MESH :
- diagnostic : Fragilité.
- effets indésirables : Anesthésie générale, Monitorage neurophysiologique peropératoire.
- mortalité : Anesthésie générale, Fragilité.
- méthodes : Monitorage neurophysiologique peropératoire.
- physiopathologie : Fragilité.
- psychologie : Fragilité.
- instrumentation : Cognition, Exercice physique, Facteurs de risque, Facteurs temps, Facteurs âges, Femelle, Force musculaire, France, Humains, Moniteurs d'évaluation de la conscience, Monitorage neurophysiologique peropératoire, Mâle, Méthode en simple aveugle, Personne âgée fragile, Plan de recherche, Protocoles cliniques, Résultat thérapeutique, Sujet âgé, Valeur prédictive des tests, État nutritionnel, Évaluation gériatrique.
English descriptors
- KwdEn :
- Age Factors (MeSH), Aged (MeSH), Anesthesia, General (adverse effects), Anesthesia, General (mortality), Clinical Protocols (MeSH), Cognition (MeSH), Consciousness Monitors (MeSH), Exercise (MeSH), Female (MeSH), Frail Elderly (MeSH), Frailty (diagnosis), Frailty (mortality), Frailty (physiopathology), Frailty (psychology), France (MeSH), Geriatric Assessment (MeSH), Humans (MeSH), Intraoperative Neurophysiological Monitoring (adverse effects), Intraoperative Neurophysiological Monitoring (instrumentation), Intraoperative Neurophysiological Monitoring (methods), Male (MeSH), Muscle Strength (MeSH), Nutritional Status (MeSH), Predictive Value of Tests (MeSH), Research Design (MeSH), Risk Factors (MeSH), Single-Blind Method (MeSH), Time Factors (MeSH), Treatment Outcome (MeSH).
- MESH :
- adverse effects : Anesthesia, General, Intraoperative Neurophysiological Monitoring.
- diagnosis : Frailty.
- instrumentation : Intraoperative Neurophysiological Monitoring.
- methods : Intraoperative Neurophysiological Monitoring.
- mortality : Anesthesia, General, Frailty.
- physiopathology : Frailty.
- psychology : Frailty.
- Age Factors, Aged, Clinical Protocols, Cognition, Consciousness Monitors, Exercise, Female, Frail Elderly, France, Geriatric Assessment, Humans, Male, Muscle Strength, Nutritional Status, Predictive Value of Tests, Research Design, Risk Factors, Single-Blind Method, Time Factors, Treatment Outcome.
Abstract
BACKGROUND
Currently, patients older than 60 years of age represent 25% of the population and are at an increased risk during surgery. Therefore, reducing postoperative morbidity and mortality is a major concern in medical research and practice. Dependence on caregivers and cognitive impairment represent two major risk factors in the elderly, especially in frail patients after surgery under general anesthesia. In this context, continuous monitoring of the depth of anesthesia using a bispectral index (BIS) sensor may reduce the occurrence of impairments by gaining better control of the anesthetic depth. The first aim of this study is to compare manual versus automated administration of intravenous anesthetics with regard to 6-month functional decline in persons aged 70 years and older. The secondary objective includes an evaluation of the influence of the frail phenotype on self-sufficiency in elderly patients after general anesthesia.
METHODS/DESIGN
After receiving ethical committee approval and written consent, a complete preoperative assessment of physiological reserve and self-sufficiency will be performed on patients more than 70 years old who are scheduled for surgery under general anesthesia. This evaluation will determine the patient's frailty status in three categories: robust, pre-frail, and frail. Then, patients will be randomized into two groups: manual administration of anesthetics guided by BIS sensor (manual group) or automated administration (automated group) with recording of the anesthesia. A second examination will be scheduled after 6 months to assess changes in functional abilities, cognitive functions, and frailty status. A priori calculation of sample size gives a population of 430 patients to be included in this multicenter trial.
DISCUSSION
This clinical study is designed to detect any postoperative complications and deaths related to the performance of the general anesthesia guided by the BIS sensor and the preoperative functional status of the elderly: robust, pre-frail, or frail.
TRIAL REGISTRATION
ClinicalTrials.gov, NCT02524327 . Registered on 10 August 2015.
DOI: 10.1186/s13063-017-1868-9
PubMed: 28298244
PubMed Central: PMC5353801
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Epidemiological and public health approaches, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U1168 VIMA: Aging and chronic diseases. 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Epidemiological and public health approaches, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U1168 VIMA: Aging and chronic diseases. Epidemiological and public health approaches, Villejuif</wicri:regionArea><placeName><settlement type="city">Villejuif</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Département de Santé Publique, AP-HP, Hôpital Sainte Périne, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Département de Santé Publique, AP-HP, Hôpital Sainte Périne, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Bizard, Antoine" sort="Bizard, Antoine" uniqKey="Bizard A" first="Antoine" last="Bizard">Antoine Bizard</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neuropsychology and Mobile Unit for Geriatric Patients, Hôpital Foch, University Versailles-Saint Quentin, Suresnes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Neuropsychology and Mobile Unit for Geriatric Patients, Hôpital Foch, University Versailles-Saint Quentin, Suresnes</wicri:regionArea><wicri:noRegion>Suresnes</wicri:noRegion><wicri:noRegion>Suresnes</wicri:noRegion></affiliation></author><author><name sortKey="Bichon, Caroline" sort="Bichon, Caroline" uniqKey="Bichon C" first="Caroline" last="Bichon">Caroline Bichon</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neuropsychology and Mobile Unit for Geriatric Patients, Hôpital Foch, University Versailles-Saint Quentin, Suresnes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Neuropsychology and Mobile Unit for Geriatric Patients, Hôpital Foch, University Versailles-Saint Quentin, Suresnes</wicri:regionArea><wicri:noRegion>Suresnes</wicri:noRegion><wicri:noRegion>Suresnes</wicri:noRegion></affiliation></author><author><name sortKey="Boichut, Nathalie" sort="Boichut, Nathalie" uniqKey="Boichut N" first="Nathalie" last="Boichut">Nathalie Boichut</name><affiliation wicri:level="3"><nlm:affiliation>Department of Anesthesiology and Critical Care Medicine, CHRU Besançon, University of Franche-Comté, Besançon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Anesthesiology and Critical Care Medicine, CHRU Besançon, University of Franche-Comté, Besançon</wicri:regionArea><placeName><region type="region">Bourgogne-Franche-Comté</region><region type="old region">Franche-Comté</region><settlement type="city">Besançon</settlement></placeName></affiliation></author><author><name sortKey="Chazot, Thierry" sort="Chazot, Thierry" uniqKey="Chazot T" first="Thierry" last="Chazot">Thierry Chazot</name><affiliation wicri:level="3"><nlm:affiliation>Department of Anesthesiology, Hôpital Foch, University Versailles-Saint Quentin, 40 rue Worth, 92150, Suresnes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Anesthesiology, Hôpital Foch, University Versailles-Saint Quentin, 40 rue Worth, 92150, Suresnes</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Suresnes</settlement></placeName></affiliation></author><author><name sortKey="Liu, Ngai" sort="Liu, Ngai" uniqKey="Liu N" first="Ngai" last="Liu">Ngai Liu</name><affiliation wicri:level="3"><nlm:affiliation>Department of Anesthesiology, Hôpital Foch, University Versailles-Saint Quentin, 40 rue Worth, 92150, Suresnes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Anesthesiology, Hôpital Foch, University Versailles-Saint Quentin, 40 rue Worth, 92150, Suresnes</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Suresnes</settlement></placeName></affiliation></author><author><name sortKey="Ankri, Joel" sort="Ankri, Joel" uniqKey="Ankri J" first="Joel" last="Ankri">Joel Ankri</name><affiliation wicri:level="1"><nlm:affiliation>UVSQ, UMR-S 1168, Université Versailles Saint-Quentin-en-Yvelines, Saint-Quentin-en-Yvelines, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>UVSQ, UMR-S 1168, Université Versailles Saint-Quentin-en-Yvelines, Saint-Quentin-en-Yvelines</wicri:regionArea><wicri:noRegion>Saint-Quentin-en-Yvelines</wicri:noRegion><wicri:noRegion>Saint-Quentin-en-Yvelines</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:affiliation>INSERM, U1168 VIMA: Aging and chronic diseases. Epidemiological and public health approaches, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U1168 VIMA: Aging and chronic diseases. Epidemiological and public health approaches, Villejuif</wicri:regionArea><placeName><settlement type="city">Villejuif</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Département de Santé Publique, AP-HP, Hôpital Sainte Périne, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Département de Santé Publique, AP-HP, Hôpital Sainte Périne, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Fischler, Marc" sort="Fischler, Marc" uniqKey="Fischler M" first="Marc" last="Fischler">Marc Fischler</name><affiliation wicri:level="3"><nlm:affiliation>Department of Anesthesiology, Hôpital Foch, University Versailles-Saint Quentin, 40 rue Worth, 92150, Suresnes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Anesthesiology, Hôpital Foch, University Versailles-Saint Quentin, 40 rue Worth, 92150, Suresnes</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Suresnes</settlement></placeName></affiliation></author></analytic><series><title level="j">Trials</title><idno type="eISSN">1745-6215</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age Factors (MeSH)</term><term>Aged (MeSH)</term><term>Anesthesia, General (adverse effects)</term><term>Anesthesia, General (mortality)</term><term>Clinical Protocols (MeSH)</term><term>Cognition (MeSH)</term><term>Consciousness Monitors (MeSH)</term><term>Exercise (MeSH)</term><term>Female (MeSH)</term><term>Frail Elderly (MeSH)</term><term>Frailty (diagnosis)</term><term>Frailty (mortality)</term><term>Frailty (physiopathology)</term><term>Frailty (psychology)</term><term>France (MeSH)</term><term>Geriatric Assessment (MeSH)</term><term>Humans (MeSH)</term><term>Intraoperative Neurophysiological Monitoring (adverse effects)</term><term>Intraoperative Neurophysiological Monitoring (instrumentation)</term><term>Intraoperative Neurophysiological Monitoring (methods)</term><term>Male (MeSH)</term><term>Muscle Strength (MeSH)</term><term>Nutritional Status (MeSH)</term><term>Predictive Value of Tests (MeSH)</term><term>Research Design (MeSH)</term><term>Risk Factors (MeSH)</term><term>Single-Blind Method (MeSH)</term><term>Time Factors (MeSH)</term><term>Treatment Outcome (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Anesthésie générale (effets indésirables)</term><term>Anesthésie générale (mortalité)</term><term>Cognition (MeSH)</term><term>Exercice physique (MeSH)</term><term>Facteurs de risque (MeSH)</term><term>Facteurs temps (MeSH)</term><term>Facteurs âges (MeSH)</term><term>Femelle (MeSH)</term><term>Force musculaire (MeSH)</term><term>Fragilité (diagnostic)</term><term>Fragilité (mortalité)</term><term>Fragilité (physiopathologie)</term><term>Fragilité (psychologie)</term><term>France (MeSH)</term><term>Humains (MeSH)</term><term>Moniteurs d'évaluation de la conscience (MeSH)</term><term>Monitorage neurophysiologique peropératoire (effets indésirables)</term><term>Monitorage neurophysiologique peropératoire (instrumentation)</term><term>Monitorage neurophysiologique peropératoire (méthodes)</term><term>Mâle (MeSH)</term><term>Méthode en simple aveugle (MeSH)</term><term>Personne âgée fragile (MeSH)</term><term>Plan de recherche (MeSH)</term><term>Protocoles cliniques (MeSH)</term><term>Résultat thérapeutique (MeSH)</term><term>Sujet âgé (MeSH)</term><term>Valeur prédictive des tests (MeSH)</term><term>État nutritionnel (MeSH)</term><term>Évaluation gériatrique (MeSH)</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Anesthesia, General</term><term>Intraoperative Neurophysiological Monitoring</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Frailty</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Fragilité</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Anesthésie générale</term><term>Monitorage neurophysiologique peropératoire</term></keywords><keywords scheme="MESH" qualifier="instrumentation" xml:lang="en"><term>Intraoperative Neurophysiological Monitoring</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Intraoperative Neurophysiological Monitoring</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Anesthesia, General</term><term>Frailty</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Anesthésie générale</term><term>Fragilité</term></keywords><keywords scheme="MESH" qualifier="méthodes" xml:lang="fr"><term>Monitorage neurophysiologique peropératoire</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Fragilité</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Frailty</term></keywords><keywords scheme="MESH" qualifier="psychologie" xml:lang="fr"><term>Fragilité</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Frailty</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Age Factors</term><term>Aged</term><term>Clinical Protocols</term><term>Cognition</term><term>Consciousness Monitors</term><term>Exercise</term><term>Female</term><term>Frail Elderly</term><term>France</term><term>Geriatric Assessment</term><term>Humans</term><term>Male</term><term>Muscle Strength</term><term>Nutritional Status</term><term>Predictive Value of Tests</term><term>Research Design</term><term>Risk Factors</term><term>Single-Blind Method</term><term>Time Factors</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" qualifier="instrumentation" xml:lang="fr"><term>Cognition</term><term>Exercice physique</term><term>Facteurs de risque</term><term>Facteurs temps</term><term>Facteurs âges</term><term>Femelle</term><term>Force musculaire</term><term>France</term><term>Humains</term><term>Moniteurs d'évaluation de la conscience</term><term>Monitorage neurophysiologique peropératoire</term><term>Mâle</term><term>Méthode en simple aveugle</term><term>Personne âgée fragile</term><term>Plan de recherche</term><term>Protocoles cliniques</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Valeur prédictive des tests</term><term>État nutritionnel</term><term>Évaluation gériatrique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>Currently, patients older than 60 years of age represent 25% of the population and are at an increased risk during surgery. Therefore, reducing postoperative morbidity and mortality is a major concern in medical research and practice. Dependence on caregivers and cognitive impairment represent two major risk factors in the elderly, especially in frail patients after surgery under general anesthesia. In this context, continuous monitoring of the depth of anesthesia using a bispectral index (BIS) sensor may reduce the occurrence of impairments by gaining better control of the anesthetic depth. The first aim of this study is to compare manual versus automated administration of intravenous anesthetics with regard to 6-month functional decline in persons aged 70 years and older. The secondary objective includes an evaluation of the influence of the frail phenotype on self-sufficiency in elderly patients after general anesthesia.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS/DESIGN</b></p><p>After receiving ethical committee approval and written consent, a complete preoperative assessment of physiological reserve and self-sufficiency will be performed on patients more than 70 years old who are scheduled for surgery under general anesthesia. This evaluation will determine the patient's frailty status in three categories: robust, pre-frail, and frail. Then, patients will be randomized into two groups: manual administration of anesthetics guided by BIS sensor (manual group) or automated administration (automated group) with recording of the anesthesia. A second examination will be scheduled after 6 months to assess changes in functional abilities, cognitive functions, and frailty status. A priori calculation of sample size gives a population of 430 patients to be included in this multicenter trial.</p></div><div type="abstract" xml:lang="en"><p><b>DISCUSSION</b></p><p>This clinical study is designed to detect any postoperative complications and deaths related to the performance of the general anesthesia guided by the BIS sensor and the preoperative functional status of the elderly: robust, pre-frail, or frail.</p></div><div type="abstract" xml:lang="en"><p><b>TRIAL REGISTRATION</b></p><p>ClinicalTrials.gov, NCT02524327 . Registered on 10 August 2015.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28298244</PMID><DateCompleted><Year>2018</Year><Month>03</Month><Day>05</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1745-6215</ISSN><JournalIssue CitedMedium="Internet"><Volume>18</Volume><Issue>1</Issue><PubDate><Year>2017</Year><Month>03</Month><Day>16</Day></PubDate></JournalIssue><Title>Trials</Title><ISOAbbreviation>Trials</ISOAbbreviation></Journal><ArticleTitle>Frailty Related to Anesthesia guided by the Index "bispectraL" (FRAIL) study: study protocol for a randomized controlled trial.</ArticleTitle><Pagination><MedlinePgn>127</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1186/s13063-017-1868-9</ELocationID><Abstract><AbstractText Label="BACKGROUND">Currently, patients older than 60 years of age represent 25% of the population and are at an increased risk during surgery. Therefore, reducing postoperative morbidity and mortality is a major concern in medical research and practice. Dependence on caregivers and cognitive impairment represent two major risk factors in the elderly, especially in frail patients after surgery under general anesthesia. In this context, continuous monitoring of the depth of anesthesia using a bispectral index (BIS) sensor may reduce the occurrence of impairments by gaining better control of the anesthetic depth. The first aim of this study is to compare manual versus automated administration of intravenous anesthetics with regard to 6-month functional decline in persons aged 70 years and older. The secondary objective includes an evaluation of the influence of the frail phenotype on self-sufficiency in elderly patients after general anesthesia.</AbstractText><AbstractText Label="METHODS/DESIGN">After receiving ethical committee approval and written consent, a complete preoperative assessment of physiological reserve and self-sufficiency will be performed on patients more than 70 years old who are scheduled for surgery under general anesthesia. This evaluation will determine the patient's frailty status in three categories: robust, pre-frail, and frail. Then, patients will be randomized into two groups: manual administration of anesthetics guided by BIS sensor (manual group) or automated administration (automated group) with recording of the anesthesia. A second examination will be scheduled after 6 months to assess changes in functional abilities, cognitive functions, and frailty status. A priori calculation of sample size gives a population of 430 patients to be included in this multicenter trial.</AbstractText><AbstractText Label="DISCUSSION">This clinical study is designed to detect any postoperative complications and deaths related to the performance of the general anesthesia guided by the BIS sensor and the preoperative functional status of the elderly: robust, pre-frail, or frail.</AbstractText><AbstractText Label="TRIAL REGISTRATION">ClinicalTrials.gov, NCT02524327 . Registered on 10 August 2015.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Le Guen</LastName><ForeName>Morgan</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Anesthesiology, Hôpital Foch, University Versailles-Saint Quentin, 40 rue Worth, 92150, Suresnes, France. m.leguen@hopital-foch.org.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Herr</LastName><ForeName>Marie</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>UVSQ, UMR-S 1168, Université Versailles Saint-Quentin-en-Yvelines, Saint-Quentin-en-Yvelines, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>INSERM, U1168 VIMA: Aging and chronic diseases. Epidemiological and public health approaches, Villejuif, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Département de Santé Publique, AP-HP, Hôpital Sainte Périne, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bizard</LastName><ForeName>Antoine</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Neuropsychology and Mobile Unit for Geriatric Patients, Hôpital Foch, University Versailles-Saint Quentin, Suresnes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bichon</LastName><ForeName>Caroline</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Neuropsychology and Mobile Unit for Geriatric Patients, Hôpital Foch, University Versailles-Saint Quentin, Suresnes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Boichut</LastName><ForeName>Nathalie</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Anesthesiology and Critical Care Medicine, CHRU Besançon, University of Franche-Comté, Besançon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chazot</LastName><ForeName>Thierry</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Anesthesiology, Hôpital Foch, University Versailles-Saint Quentin, 40 rue Worth, 92150, Suresnes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Ngai</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Anesthesiology, Hôpital Foch, University Versailles-Saint Quentin, 40 rue Worth, 92150, Suresnes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ankri</LastName><ForeName>Joel</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>UVSQ, UMR-S 1168, Université Versailles Saint-Quentin-en-Yvelines, Saint-Quentin-en-Yvelines, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>INSERM, U1168 VIMA: Aging and chronic diseases. Epidemiological and public health approaches, Villejuif, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Département de Santé Publique, AP-HP, Hôpital Sainte Périne, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fischler</LastName><ForeName>Marc</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Anesthesiology, Hôpital Foch, University Versailles-Saint Quentin, 40 rue Worth, 92150, Suresnes, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><DataBankList CompleteYN="Y"><DataBank><DataBankName>ClinicalTrials.gov</DataBankName><AccessionNumberList><AccessionNumber>NCT02524327</AccessionNumber></AccessionNumberList></DataBank></DataBankList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016448">Multicenter Study</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>03</Month><Day>16</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Trials</MedlineTA><NlmUniqueID>101263253</NlmUniqueID><ISSNLinking>1745-6215</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000367" MajorTopicYN="N">Age Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000768" MajorTopicYN="Y">Anesthesia, General</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002985" MajorTopicYN="N">Clinical Protocols</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003071" MajorTopicYN="N">Cognition</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D056805" MajorTopicYN="Y">Consciousness Monitors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015444" MajorTopicYN="N">Exercise</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016330" MajorTopicYN="Y">Frail Elderly</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000073496" MajorTopicYN="N">Frailty</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName><QualifierName UI="Q000523" MajorTopicYN="N">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005602" MajorTopicYN="N">France</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015577" MajorTopicYN="N">Geriatric Assessment</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D064795" MajorTopicYN="N">Intraoperative Neurophysiological Monitoring</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName><QualifierName UI="Q000295" MajorTopicYN="Y">instrumentation</QualifierName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053580" MajorTopicYN="N">Muscle Strength</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009752" MajorTopicYN="N">Nutritional Status</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011237" MajorTopicYN="N">Predictive Value of Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012107" MajorTopicYN="N">Research Design</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016037" MajorTopicYN="N">Single-Blind Method</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Anesthesia</Keyword><Keyword MajorTopicYN="Y">Elderly</Keyword><Keyword MajorTopicYN="Y">Frailty</Keyword><Keyword MajorTopicYN="Y">Outcome</Keyword><Keyword MajorTopicYN="Y">Recovery</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>07</Month><Day>02</Day></PubMedPubDate><PubMedPubDate 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2001 Mar;56(3):M146-56</Citation><ArticleIdList><ArticleId IdType="pubmed">11253156</ArticleId></ArticleIdList></Reference><Reference><Citation>Public Health Nutr. 2010 Nov;13(11):1847-54</Citation><ArticleIdList><ArticleId IdType="pubmed">20196910</ArticleId></ArticleIdList></Reference><Reference><Citation>Age Ageing. 2012 Mar;41(2):142-7</Citation><ArticleIdList><ArticleId IdType="pubmed">22345294</ArticleId></ArticleIdList></Reference><Reference><Citation>J Am Geriatr Soc. 2006 Jun;54(6):991-1001</Citation><ArticleIdList><ArticleId IdType="pubmed">16776798</ArticleId></ArticleIdList></Reference><Reference><Citation>J Surg Oncol. 2015 Nov;112(6):681-2</Citation><ArticleIdList><ArticleId IdType="pubmed">26488427</ArticleId></ArticleIdList></Reference><Reference><Citation>Anesthesiology. 2012 Jun;116(6):1195-203</Citation><ArticleIdList><ArticleId IdType="pubmed">22546967</ArticleId></ArticleIdList></Reference><Reference><Citation>J Am Coll Surg. 2015 May;220(5):904-11.e1</Citation><ArticleIdList><ArticleId IdType="pubmed">25907870</ArticleId></ArticleIdList></Reference><Reference><Citation>J Clin Epidemiol. 1998 Apr;51(4):315-21</Citation><ArticleIdList><ArticleId IdType="pubmed">9539888</ArticleId></ArticleIdList></Reference><Reference><Citation>JAMA. 1963 Sep 21;185:914-9</Citation><ArticleIdList><ArticleId IdType="pubmed">14044222</ArticleId></ArticleIdList></Reference><Reference><Citation>J Telemed Telecare. 2013 Jan;19(1):45-54</Citation><ArticleIdList><ArticleId IdType="pubmed">23390209</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Geriatr Med. 2011 Feb;27(1):17-26</Citation><ArticleIdList><ArticleId IdType="pubmed">21093719</ArticleId></ArticleIdList></Reference><Reference><Citation>Circulation. 2002 Mar 12;105(10):1257-67</Citation><ArticleIdList><ArticleId IdType="pubmed">11889023</ArticleId></ArticleIdList></Reference><Reference><Citation>Blood Transfus. 2011 Apr;9(2):189-217</Citation><ArticleIdList><ArticleId IdType="pubmed">21527082</ArticleId></ArticleIdList></Reference><Reference><Citation>Br J Anaesth. 2011 Nov;107(5):749-56</Citation><ArticleIdList><ArticleId IdType="pubmed">21828343</ArticleId></ArticleIdList></Reference><Reference><Citation>JAMA Surg. 2016 Jun 1;151(6):538-45</Citation><ArticleIdList><ArticleId IdType="pubmed">26791334</ArticleId></ArticleIdList></Reference><Reference><Citation>Ann Fr Anesth Reanim. 2001 Aug;20(7):592-9</Citation><ArticleIdList><ArticleId IdType="pubmed">11530746</ArticleId></ArticleIdList></Reference><Reference><Citation>J Gerontol A Biol Sci Med Sci. 2009 Feb;64(2):195-8</Citation><ArticleIdList><ArticleId IdType="pubmed">19251914</ArticleId></ArticleIdList></Reference><Reference><Citation>Anesthesiology. 1999 Sep;91(3):693-700</Citation><ArticleIdList><ArticleId IdType="pubmed">10485781</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2013 Mar 2;381(9868):752-62</Citation><ArticleIdList><ArticleId IdType="pubmed">23395245</ArticleId></ArticleIdList></Reference><Reference><Citation>Gerontologist. 1970 Spring;10(1):20-30</Citation><ArticleIdList><ArticleId IdType="pubmed">5420677</ArticleId></ArticleIdList></Reference><Reference><Citation>Anesth Analg. 2011 Mar;112(3):546-57</Citation><ArticleIdList><ArticleId IdType="pubmed">21233500</ArticleId></ArticleIdList></Reference><Reference><Citation>Soins Gerontol. 2011 Jan-Feb;(87):29-32</Citation><ArticleIdList><ArticleId IdType="pubmed">21416904</ArticleId></ArticleIdList></Reference><Reference><Citation>J Am Geriatr Soc. 2012 Aug;60(8):1487-92</Citation><ArticleIdList><ArticleId IdType="pubmed">22881367</ArticleId></ArticleIdList></Reference><Reference><Citation>Anesth Analg. 2005 Jan;100(1):4-10</Citation><ArticleIdList><ArticleId IdType="pubmed">15616043</ArticleId></ArticleIdList></Reference><Reference><Citation>Anesthesiology. 2006 Dec;105(6):1087-97</Citation><ArticleIdList><ArticleId IdType="pubmed">17122571</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>France</li></country><region><li>Bourgogne-Franche-Comté</li><li>Franche-Comté</li><li>Île-de-France</li></region><settlement><li>Besançon</li><li>Paris</li><li>Suresnes</li><li>Villejuif</li></settlement></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Le Guen, Morgan" sort="Le Guen, Morgan" uniqKey="Le Guen M" first="Morgan" last="Le Guen">Morgan Le Guen</name></region><name sortKey="Ankri, Joel" sort="Ankri, Joel" uniqKey="Ankri J" first="Joel" last="Ankri">Joel Ankri</name><name sortKey="Ankri, Joel" sort="Ankri, Joel" uniqKey="Ankri J" first="Joel" last="Ankri">Joel Ankri</name><name sortKey="Ankri, Joel" sort="Ankri, Joel" uniqKey="Ankri J" first="Joel" last="Ankri">Joel Ankri</name><name sortKey="Bichon, Caroline" sort="Bichon, Caroline" uniqKey="Bichon C" first="Caroline" last="Bichon">Caroline Bichon</name><name sortKey="Bizard, Antoine" sort="Bizard, Antoine" uniqKey="Bizard A" first="Antoine" last="Bizard">Antoine Bizard</name><name sortKey="Boichut, Nathalie" sort="Boichut, Nathalie" uniqKey="Boichut N" first="Nathalie" last="Boichut">Nathalie Boichut</name><name sortKey="Chazot, Thierry" sort="Chazot, Thierry" uniqKey="Chazot T" first="Thierry" last="Chazot">Thierry Chazot</name><name sortKey="Fischler, Marc" sort="Fischler, Marc" uniqKey="Fischler M" first="Marc" last="Fischler">Marc Fischler</name><name sortKey="Herr, Marie" sort="Herr, Marie" uniqKey="Herr M" first="Marie" last="Herr">Marie Herr</name><name sortKey="Herr, Marie" sort="Herr, Marie" uniqKey="Herr M" first="Marie" last="Herr">Marie Herr</name><name sortKey="Herr, Marie" sort="Herr, Marie" uniqKey="Herr M" first="Marie" last="Herr">Marie Herr</name><name sortKey="Liu, Ngai" sort="Liu, Ngai" uniqKey="Liu N" first="Ngai" last="Liu">Ngai 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